产品名称

6-Phosphogluconic Dehydrogenase from yeast

别 称

6-Phospho-D-gluconate:NADP₊2-oxidoreductase (decarboxylating), 6-Phosphogluconic Dehydrogenase from yeast

含 量

≥3.0 units/mg solid

CAS  NO.

9073-95-4

MDL  number

MFCD00130317

适用范围

生物试剂

l  理化信息

外 观

冻干粉

l  生物学信息

生物活性/药理作用

Enzyme activity is determined by measuring the reduction of NAD₊ or NADP₊. High levels of NADPH are believed to inhibit the enzyme, while 6-phosphogluconate acts to activate the enzyme.

应 用

6-phosphoglyconic dehydrogenase (6PGD) is a  key enzyme in the oxidative portion of the hexose monophosphate shunt. It is specific for oxidized nicotinamide adenine dinucleotide phosphate (NADP₊) . 6-phosphogluconate dehydrogenase is involved in the production of ribulose 5-phosphate, which is involved in nucleotide synthesis and the pentose phosphate pathway by generating NADPH. 6-phosphogluconate dehydrogenase is used to study nucleotide synthesis, glucose metabolism, and the protection of  cells from oxidative damage

有效单位定义

One unit will oxidize 1.0 μmole of 6-phospho-D-gluconate to D-ribulose 5-phosphate and CO2 per min at pH 7.4 at  37 °C in the presence of NADP₊.

l  包装与存储

存储温度

2-8°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov