产品名称

GSK2194069

一般描述

GSK2194069 is a fatty acid synthase (FAS) inhibitor.

别称

(S)-4-(4-(Benzofuran-5-yl)phenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5(4H)-one

纯 度

≥97.0%(HPLC)

CAS NO.

1332331-08-4

分子式

C²⁵H²⁴N⁴O³

分子量

428.48

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至浅棕色固体

溶解性(25℃)

DMSO

~5mg/mL(warmed)

l  生物学信息

生物活性/药理作用

GSK2194069 is a fatty acid synthase (FAS) inhibitor. GSK2194069 is a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS with an IC₅₀ of 7.7 ± 4.1 nM for the overall hFAS reaction. FAS is upregulated in some cancers, including prostate cancer. GSK2194069 was found to inhibit tumour growth in prostate cancer C42b cell xenografts generated in Nod-SCID-gamma mice. Cellular FAS inhibition reduced cell growth were also demonstrated in non-small-cell lung (A549) cancer cell lines with an average EC₅₀ of 15 ± 0.5 nM.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov