产品名称

Cerivastatin sodium salt hydrate

一般描述

Accumulated macrophages in atherosclerotic plaques result in plaque rupture and thrombus formation.

别称

(3R,5S,6E)-7-[4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic   acid sodium salt hydrate, Rivastatin hydrate

纯 度

≥98.0%(HPLC)

CAS NO.

143201-11-0 (anhydrous)

分子式

C²⁶H³³FNNaO⁵ · xH²O

分子量

481.53 (anhydrous basis)

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至棕褐色固体

溶解性(25℃)

水

≥5mg/mL

l  生物学信息

生物活性/药理作用

Accumulated macrophages in atherosclerotic plaques result in plaque rupture and thrombus formation. Cerivastatin suppresses the growth of macrophages and decreases the of matrix metalloproteinases and tissue factor molecules, thus reduces acute coronary events.

Cerivastatin sodium is an HMG-CoA reductase inhibitor. HMG-CoA is a key enzyme in the production of cholesterol.

应用

Cerivastatin sodium salt hydrate has been used as a supplement in cell culture.

Cerivastatin sodium salt hydrate may be used in cell signaling studies.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov