产品名称

Antimycin A from Streptomyces sp.

一般描述

Antimycin is produced by Streptomyces species. It inhibits mitochondrial electron transport chain complex III and favors reactive oxygen species (ROS) production, impairing mitochondrial depolarization. It inhibits nitric oxide-mediated apoptosis and modulatescytochrome C release. It suppresses tumorigenesis in lung cancer cells and could be a potential therapeutic agent.

别 称

Antipiricullin

CAS NO.

1397-94-0

分子式

C²⁸H⁴⁰N²O⁹

分子量

548.633

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至黄色粉末

l  生物学信息

生物活性/药理作用

Inhibitor of electron transfer at complex III. Induces apoptosis.

应 用

Antimycin A from Streptomyces sp. has been used:

• as a respiratory chain inhibitor in neuronal cultures

• in organello ATP production assay in Trypanosoma brucei cells

• in respiration assay for papillary thyroid carcinoma (PTC) cell lines

Antimycin A has been used to study the specific sites of reactive oxygen species production in mitochondria isolated from skeletal muscle of chronic obstructive pulmonary disease patients, and its relationship with local oxidative stress induced by exercise

l  存储

存储温度

−20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov