产品名称

Colcemid(Demecolcine)( 地美可辛)

一般描述

Colcemid is also known as demecolcine. Its generic name is N-methyl-N-deacetyl-colchicine. Colcemid depolymerizes microtubules and blocks mitosis at metaphase.

别 称

Demecolcine, N-Deacetyl-N-methylcolchicine

纯 度

≥98%(HPLC)

CAS NO.

477-30-5

分子式

C²¹H²⁵NO⁵

分子量

371.433

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

淡黄色到黄色、浅米色到米色、黄绿色固体

溶解性(25°C)

乙醇

soluble

l  生物学信息

生物活性/药理作用

Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.

应 用

Colcemid inhibits the formation of mitotic spindles. It is used to increase the percentage of metaphase cells for chromosome analysis.

l  存储

存储温度

−20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov