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Imatinib Mesylate

商品编号: TL0006
图示 货号 库存 价格(¥) 数量

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详细介绍

l  基本信息

产品名称

甲磺酸伊马替尼(Imatinib Mesylate)

一般描述

Imatinib mesylate is a tyrosine kinase inhibitor with antineoplastic activity.

别 称

4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamide methanesulfonate, 4-[(4-Methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide   mesylate, CGP 57148, Genfatinib, Glivec, Imatinib methanesulfonate, STI-571.

纯 度

≥99%   (HPLC)

CAS NO.

220127-57-1

分子式

C30H35N7O4S

分子量

589.71

适用范围

生物试剂,适用于细胞培养等

l  理化信息

外 观

白色或类白色至黄色固体

溶解度(25℃)

DMSO

≥50mg/mL

乙醇

Insoluble

≥50mg/mL

l  生物学信息

生物活性/药理作用

Imatinib Mesylate is the mesylate salt of imatinib, a tyrosine kinase inhibitor with antineoplastic activity. Imatinib binds to an intracellular pocket located within tyrosine kinases (TK), thereby inhibiting ATP binding and preventing phosphorylation and the subsequent activation of growth receptors and their downstream signal transduction pathways. This agent inhibits TK encoded by the bcr-abl oncogene as well as receptor TKs encoded by the c-kit and platelet-derived growth  factor receptor (PDGFR) oncogenes. Inhibition of the bcr-abl TK results in decreased proliferation and enhanced apoptosis in malignant cells of Philadelphia-positive (Ph+) hematological malignancies such as CML and ALL; effects on c-kit TK activity inhibit mast-cell and cellular proliferation in those diseases overexpressing c-kit, such as mastocytosis and gastrointestinal stromal tumor (GIST).

l  包装与存储

包 装

50mg; 250mg; 1g

存储温度

0-5

l  注意事项及免责声明

本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。

l  参考文献

1.    https://ncit.nci.nih.gov

2.  https://www.ncbi.nlm.nih.gov/mesh/