产品名称

尼卡地平(Nicardipine)

一般描述

Nicardipine is a potent calcium channel  blockader with marked vasodilator action.

别 称

5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; Nicardipinum; Nicardipino; Cardene

纯 度

≥99%(HPLC)

CAS NO.

55985-32-5

分子式

C²⁶H²⁹N³O⁶

分子量

479.533

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

棕黄色粘稠状物

l  生物学信息

生物活性/药理作用

Nicardipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and  Prinzmetal's variant angina. Nicardipine is similar to other peripheral  vasodilators. Nicardipine inhibits the influx of extra cellular calcium  across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the  myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

l  包装与存储

包 装

250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov