产品名称

盐酸阿霉素(Doxorubicin HCl)

一般描述

Doxorubicin Hydrochloride is an anthracycline antibiotic with antineoplastic activity.

别 称

(7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride;  盐酸多柔比星;  AdriaMycin HCl;

纯 度

≥98%(HPLC)

CAS NO.

25316-40-9

分子式

C²⁷H²⁹NO¹¹·HCl

分子量

579.983

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

橙红色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

Very slightly soluble

水

≥15mg/mL

l  生物学信息

生物活性/药理作用

Doxorubicin Hydrochloride is the hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis.  Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA ed complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.

l  包装与存储

包 装

50mg;  250mg; 1g

存储温度

-5-0℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov