产品名称

索非布韦(Sofosbuvir)

一般描述

Sofosbuvir(索非布韦) is a uridine monophosphate analog inhibitor of HCV polymerase NS5B that is used as an antiviral agent in the treatment of chronic hepatitis.

别 称

propan-2-yl(2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate; 索非布韦,索氟布韦;索菲布韦;GS-7977;PSI7977

纯 度

≥98%(HPLC)

CAS NO.

1190307-88-0

分子式

C²²H²⁹FN³O⁹P

分子量

529.458

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥50mg/mL

水

≥5mg/mL

l  生物学信息

生物活性/药理作用

Sofosbuvir acts against HCV and is categorized as a direct-acting antiviral agent (DAA). At a dose 3 times the recommended dose, sofosbuvir does not prolong QTc to any clinically relevant extent [FDA Label].

Sofosbuvir is an orally available nucleotide prodrug and a hepatitis C virus (HCV) NS5B polymerase inhibitor with potential HCV inhibiting activity. Upon oral administration, sofosbuvir is metabolized to 2'-deoxy-2'-alpha-fluoro-beta-C-methyluridine-5'-monophosphate, which is then converted into the active triphosphate nucleotide that inhibits the NS5B  polymerase, thereby preventing viral replication. The HCV NS5B protein, an  RNA-dependent RNA polymerase, is essential for the replication of the viral  HCV RNA genome.

l  包装与存储

包 装

25mg; 100mg; 500mg

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov