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Lenvatinib

商品编号: TL0147
图示 货号 库存 价格(¥) 数量

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详细介绍

l  基本信息

产品名称

乐伐替尼(Lenvatinib)

一般描述

Lenvatinib(乐伐替尼) is a synthetic, orally available inhibitor of VEGFR2 tyrosine kinase with potential antineoplastic activity.

别 称

4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxyquinoline-6-carboxamide; E7080

纯 度

≥98%(HPLC)

CAS NO.

417716-92-8

分子式

C21H19ClN4O4

分子量

426.857

适用范围

生物试剂,适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25)

DMSO

≥25mg/mL

乙醇

Insoluble

Insoluble

l  生物学信息

生物活性/药理作用

Based on x-ray crystallography and kinetic interaction studies, lenvatinib binds to the adenosine 5'-triphosphate binding site of VEGFR2 and to a neighbouring region via a cyclopropane ring and thereby inhibits tyrosine kinase activity and associated signalling pathways.

Lenvatinib is a synthetic, orally available inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR/FLK-1) tyrosine kinase with potential antineoplastic activity. Lenvatinib blocks VEGFR2 activation by VEGF, resulting in inhibition of the  VEGF receptor signal transduction pathway, decreased vascular endothelial cell migration and proliferation, and vascular endothelial cell apoptosis.

l  包装与存储

包 装

25mg; 100mg; 500mg

存储温度

0-5

l  注意事项及免责声明

本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov