产品名称

卡铂(Carboplatin)

一般描述

Carboplatin(卡铂) is a second-generation platinum compound with a broad spectrum of antineoplastic properties.

别 称

cis-Diammine(1,1-cyclobutanedicarboxylato)  platinum; Carboplatinum;  Paraplatin; Cbdca;JM-8;CBDCA;NSC 241240

纯 度

≥99%(HPLC)

CAS NO.

41575-94-4

分子式

[C⁴H⁶(CO²)²]Pt(NH³)²

分子量

371.25

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25℃)

DMSO

Insoluble

乙醇

Insoluble

水

~10mg/mL

l  生物学信息

生物活性/药理作用

Carboplatin is a second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as  GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-s, as well as DNA-protein cross-s. These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition. This agent possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic.

l  包装与存储

包 装

25mg; 100mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov