Combretastatin A4
商品编号:
TL0150
备注:
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详细介绍
l 基本信息 |
产品名称 | 康普瑞汀(Combretastatin A4) |
一般描述 | Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM. |
别 称 | 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol; Combretastatin-A4; Crc 87-09; NSC 817373 |
纯 度 | ≥99%(HPLC) | CAS NO. | 117048-59-6 |
分子式 | C18H20O5 | 分子量 | 316.353 |
适用范围 | 生物试剂,适用于细胞培养等 |
l 理化信息 |
外 观 | 白色至类白色固体 |
溶解性(25℃) | DMSO | ≥50mg/mL |
乙醇 | ≥20mg/mL |
水 | Insoluble |
l 生物学信息 |
生物活性/药理作用 | Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumor vasculature to inhibit angiogenesis. It
inhibits tubulin polymerization at the colchicine-binding site of beta-tubulin. It has antitumor activity by inhibiting AKT function in human gastric cells. The inhibited AKT activation causes decreased cell proliferation, cell cycle arrest, and reduced in vitro migration/invasiveness and in vivo metastatic ability. Combretastatin A4 is a natural stilbenoid
phenol. |
l 包装与存储 |
包 装 | 25mg;100mg; 500mg |
存储温度 | 0-5℃ |
l 注意事项及免责声明 |
本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |