产品名称

喹硫平(Quetiapine)

一般描述

Quetiapine(喹硫平) is a dibenzothiazepine derivative with antipsychotic property.

别 称

2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol;  Seroquel

纯 度

≥95%(HPLC)

CAS NO.

111974-69-7

分子式

C²¹H²⁵N³O²S

分子量

383.51

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

棕色或黑褐色粘稠物

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

N/A

水

N/A

l  生物学信息

生物活性/药理作用

Quetiapine is a psychotropic agent  belonging to the chemical class of benzisoxazole derivatives and is indicated for the treatment of schizophrenia. Quetiapine is a selective monoaminergic  antagonist with high affinity for the serotonin Type 2 (5HT2), and dopamine  type 2 (D2) receptors. Quetiapine is an antagonist at serotonin 5-HT1A and  5HT2, dopamine D1 and D2, histamine H1, and adrenergic alpha 1 and alpha 2 receptors. Quetiapine has no significant affinity for cholinergic muscarinic  or benzodiazepine receptors. Drowsiness and orthostatic hypotension associated with use of quetiapine may be explained by its antagonism of histamine H1 and adrenergic alpha 1 receptors, respectively. Quetiapine's  antagonism of adrenergic a1 receptors may explain the orthostatic hypotension observed with this drug.

l  包装与存储

包 装

250mg; 1g

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov