产品名称

喜树碱(Camptothecin)

一般描述

Camptothecin(喜树碱)  is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA Ttopoisomerase I (Topo I).

别 称

Camptothecine; (S)-(+)-Camptothecin

纯 度

≥98%(HPLC)

CAS NO.

7689-03-4

分子式

C²⁰H¹⁶N²O⁴

分子量

348.358

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

黄色固体

溶解性(25℃)

DMSO

~3mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Camptothecin demonstrated strong anticancer activity in preliminary clinical trials but also low solubility and adverse drug reaction. Camptothecin is believed to be a potent topoisomerase inhibitor that interferes with the essential function of topoisomerase in DNA replication.

Camptothecin is an alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication  machinery.

l  包装与存储

包 装

50mg; 250mg; 1g

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov