产品名称

甘草次酸(Enoxolone)

一般描述

Enoxolone(甘草次酸) is a pentacyclic triterpenoid aglycone metabolite of glycyrrhizin, which is a  product of the plant Glycyrrhiza glabra (licorice), with potential expectorant, and gastrokinetic activities.

别 称

3β-Hydroxy-11-oxo-18β,20β-olean-12-en-29-oic  acid; Enoxolone; Uralenic acid; 18-beta-Glycyrrhetinic acid

纯 度

≥98%(HPLC)

CAS NO.

471-53-4

分子式

C³⁰H⁴⁶O⁴

分子量

470.694

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Enoxolone is a pentacyclic triterpenoid aglycone metabolite of glycyrrhizin, which is a product of the plant Glycyrrhiza glabra (licorice), with potential expectorant, and gastrokinetic activities. After administration, enoxolone inhibits the metabolism of prostaglandins by both 15-hydroxyprostaglandin dehydrogenase [NAD(+)] and prostaglandin reductase 2. Therefore, this agent potentiates the activity of prostaglandin E2 and F2alpha, which inhibits gastric secretion while stimulating pancreatic secretion and the secretion of intestinal and respiratory mucus, leading to increased intestinal motility and antitussive effects. Additionally, this  agent inhibits 11 beta-hydroxysteroid dehydrogenase and other enzymes involved in the conversion of cortisol to cortisone in the kidneys.

l  包装与存储

包 装

1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov