产品名称

汉防己甲素(Tetrandrine)

一般描述

Tetrandrine(汉防己甲素),  a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a non-selective calcium channel blocker.

别 称

(1β)-6,6′,7,12-Tetramethoxy-2,2′-dimethylberbaman; 汉防己碱;  (+)-Tetrandrine; Tetrandrin; Fanchinine; D-Tetrandrine

纯 度

≥98%(HPLC)

CAS NO.

518-34-3

分子式

C³⁸H⁴²N²O⁶

分子量

622.75

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

~1mg/mL

乙醇

~2mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Tetrandrine is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant Radix stephania tetrandrae. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the cell cycle and apoptosis in various cell types, resulting in immunosuppressive, anti-proliferative and free radical scavenging effects. This agent also increases glucose utilization by enhancing hepatocyte glycogen synthesis, resulting in the lowering of plasma glucose.

l  包装与存储

包 装

5mg; 25mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov