产品名称

盐酸甲基苄肼(Procarbazine hydrochloride)

一般描述

Procarbazine Hydrochloride(盐酸甲基苄肼) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities.

别 称

4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide;hydrochloride; Matulane; Natunalar

纯 度

≥99%(HPLC)

CAS NO.

366-70-1

分子式

C¹²H²⁰ClN³O

分子量

257.762

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至黄白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥50mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Procarbazine Hydrochloride is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.

l  包装与存储

包 装

1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov