产品名称

盐酸表阿霉素(Epirubicin hydrochloride)

一般描述

Epirubicin hydrochloride(盐酸表阿霉素), an anthracycline which is the 4'-epi-isomer of doxorubicin, exerts its  antitumor effects by interference with the synthesis and function of DNA.

别 称

(7S,9S)-7-[(2R,4S,5R,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride;  盐酸表柔比星;Ellence;  Pharmorubicin; Farmorubicin;

纯 度

≥98%(HPLC)

CAS NO.

56390-09-1

分子式

C²⁷H³⁰ClNO¹¹

分子量

579.983

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

橙红色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

Insoluble

水

≥50mg/mL

l  生物学信息

生物活性/药理作用

Epirubicin Hydrochloride is the hydrochloride salt of the 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent also produces toxic  free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.

l  包装与存储

包 装

10mg; 50mg; 250mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov