产品名称

盐酸吉西他滨(Gemcitabine hydrochloride)

一般描述

Gemcitabine Hydrochloride(盐酸吉西他滨) is the hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity.

别 称

4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydrochloride;  Gemzar; Gemcitabine HCl; LY188011 hydrochloride

纯 度

≥99%(HPLC)

CAS NO.

122111-03-9

分子式

C⁹H¹²ClF²N³O⁴

分子量

299.659

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

Insoluble

乙醇

Insoluble

水

≥15mg/mL

l  生物学信息

生物活性/药理作用

Gemcitabine Hydrochloride is the hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP nhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.

l  包装与存储

包 装

250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov