产品名称

美法仑(Melphalan)

一般描述

Melphalan(美法仑) is a phenylalanine derivative of nitrogen mustard with antineoplastic activity.

别 称

(2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid; Melfalan; Alkeran; Phenylalanine mustard;L-PAM

纯 度

≥95.5%(HPLC)

CAS NO.

148-82-3

分子式

C¹³H¹⁸Cl²N²O²

分子量

305.199

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

~10mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Melphalan is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-ing guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition,  these drugs add methyl or other alkyl groups onto molecules where they do not  belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific.  Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.

Melphalan is a phenylalanine derivative of  nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-ages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells.

l  包装与存储

包 装

250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov