产品名称

瑞替加滨(Retigabine)

一般描述

Retigabine(瑞替加滨) is a novel anticonvulsant with activity in a broad range of seizure models.

别 称

ethyl 4-(4-fluorobenzylamino)-2-aminophenylcarbamate; Ezogabine; D-23129; Trobalt

纯 度

≥98%(HPLC)

CAS NO.

150812-12-7

分子式

C¹⁶H¹⁸FN³O²

分子量

303.337

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥30mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

As compared to other antiepileptic agents, ezogabine is unique in that it selectively activates potassium ion channels Kv 7.2-Kv7.5 and not cardiac Kv 7.1, thereby avoiding cardiac side effects. The antiepileptics, as a drug class, are routinely used in the treatment of a number of disease states in addition to epilepsy. Ezogabine is highly efficacious in a broad-spectrum of in vivo epilepsy and seizure models. A comparison of antiepileptic form activity of ezogabine with that of conventional anticonvulsants in in vitro models suggests that retigabine is especially likely to be useful in the treatment of pharmacoresistant epilepsy. Retigabine clearly attenuates pain-like behaviors in various animal models of neuropathic pain; it may also prove to be useful in treatment of clinical anxiety disorders.Clinical data obtained thus far indicate that retigabine is well tolerated in humans when titrated up to its therapeutic dose range.No tolerance, drug dependence, or withdrawal liability has been reported.Thus, retigabine may prove to be useful in the treatment of a diverse range of disease states in which neuronal hyperexcitability is a common underlying factor.

l  包装与存储

包 装

10mg; 50mg; 250mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov