产品名称

更昔洛韦(Ganciclovir)

一般描述

Ganciclovir(更昔洛韦) is a Cytomegalovirus Nucleoside Analog DNA Polymerase Inhibitor and Nucleoside Analog Antiviral.

别 称

2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one; Cytovene; Vitrasert; Hydroxyacyclovir

纯 度

≥98%(HPLC)

CAS NO.

82410-32-0

分子式

C⁹H¹³N⁵O⁴

分子量

255.234

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥20mg/mL

乙醇

Insoluble

水

Slightly  soluble

l  生物学信息

生物活性/药理作用

Ganciclovir is a synthetic nucleoside analogue of 2'-deoxyguanosine that inhibits replication of herpes viruses both in vitro and in vivo. Sensitive human viruses include cytomegalovirus  (CMV), herpes simplex virus -1 and -2 (HSV-1, HSV-2), Epstein-Barr virus  (EBV) and varicella zoster virus (VZV), however clinical studies have been limited to assessment of efficacy in patients with CMV infection. Ganciclovir is a prodrug that is structurally similar to acyclovir. It inhibits virus replication by its encorporation into viral DNA. This encorporation inhibits  dATP and leads to defective DNA, ceasing or retarding the viral machinery required to spread the virus to other cells.

l  包装与存储

包 装

1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov