产品名称

甲苯咪唑(Mebendazole)

一般描述

Mebendazole(甲苯咪唑)  is a synthetic benzimidazole derivate and anthelmintic agent that acts by interfering with Carbohydrate metabolism and inhibiting polymerization of  Microtubules.

别 称

methyl N-(6-benzoyl-1H-benzimidazol-2-yl)carbamate; Vermox;  Telmin; Mebenvet; Pantelmin

纯 度

≥98%(HPLC)

CAS NO.

31431-39-7

分子式

C¹⁶H¹³N³O³

分子量

295.298

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或黄白色固体

溶解性(25℃)

DMSO

~5mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Mebendazole is a (synthetic) broad-spectrum anthelmintic. The principal mode of action for Mebendazole is by its inhibitory effect on tubulin polymerization which results in the loss of cytoplasmic microtubules.

Mebendazole is a synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. This results in a depletion of glycogen stores and leads to reduced formation of ATP required for survival and reproduction of the helminth. This eventually causes the helminths death.

l  包装与存储

包 装

1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov