产品名称

克霉唑(Clotrimazole)

一般描述

Clotrimazole(克霉唑) is an imidazole derivative with a broad spectrum of antimycotic activity.

别 称

1-[(2-chlorophenyl)-diphenylmethyl]imidazole; Lotrimin; Canesten; Mycelex; Mycosporin

纯 度

≥98%(HPLC)

CAS NO.

23593-75-1

分子式

C²²H¹⁷ClN²

分子量

344.842

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥10mg/mL

乙醇

≥50mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Clotrimazole, an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. Betamethasone and clotrimazole are used together to treat cutaneous tinea infections. In studies in fungal cultures, the minimum fungicidal concentration of clotrimazole caused leakage of intracellular phosphorous compounds into the ambient medium with concomitant breakdown of cellular nucleic acids, and accelerated potassium etflux. Both of these events began rapidly and extensively after addition of the drug to the cultures. The primary action of clotrimazole is against dividing and growing organisms.

Clotrimazole is a synthetic, imidazole  derivate with broad-spectrum, antifungal activity. Clotrimazole inhibits biosynthesis of sterols, particularly ergosterol, an essential component of  the fungal cell membrane, thereby damaging and affecting the permeability of  the cell membrane. This results in leakage and loss of essential  intracellular compounds, and eventually causes cell lysis.

l  包装与存储

包 装

1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov