产品名称

盐酸肼屈嗪(Hydralazine hydrochloride)

一般描述

Hydralazine Hydrochloride(盐酸肼屈嗪) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities.

别 称

1-Hydrazinophthalazine hydrochloride

纯 度

≥98%(HPLC)

CAS NO.

304-20-1

分子式

C⁸H⁸N⁴ · HCl

分子量

196.64

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

溶解性(25℃)

DMSO

Insoluble

乙醇

Insoluble

水

≥30mg/mL

l  生物学信息

生物活性/药理作用

Hydralazine Hydrochloride is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release and interferes with smooth muscle cell calcium influx, resulting in arterial vasodilatation. This agent also inhibits the phosphorylation of myosin protein and chelation of trace metals required for smooth muscle contraction, resulting in an increase in heart rate, stroke  volume and cardiac output. In addition to its cardiovascular effects, hydralazine inhibits DNA methyltransferase, which may result in inhibition of DNA methylation in tumor cells.

l  包装与存储

包 装

1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov