产品名称

克拉霉素(Clarithromycin)

一般描述

Clarithromycin(克拉霉素) is a Macrolide Antimicrobial.

纯 度

≥98%(HPLC)

CAS NO.

81103-11-9

分子式

C³⁸H⁶⁹NO¹³

分子量

747.95

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥20mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Clarithromycin is a macrolide antibiotic whose spectrum of activity includes many gram-positive (Staphylococcus aureus, S. pneumoniae, and S. pyogenes) and gram-negative aerobic bacteria (Haemophilus influenzae, H. parainfluenzae, and Moraxella catarrhalis), many anaerobic bacteria, some mycobacteria, and some other organisms including Mycoplasma, Ureaplasma, Chlamydia, Toxoplasma, and Borrelia. Other aerobic  bacteria that clarithromycin has activity against include C. pneumoniae and  M. pneumoniae. Clarithromycin has an in-vitro activity that is similar or greater than that of erythromycin against erythromycin-susceptible organisms.Clarithromycin is usually bacteriostatic, but may be bactericidal depending on the organism and the drug concentration.

Clarithromycin is a semisynthetic 14-membered ring macrolide antibiotic. Clarithromycin binds to the 50S ribosomal subunit and inhibits RNA-dependent protein synthesis in susceptible organisms. Clarithromycin has been shown to eradicate gastric MALT (mucosa-associated lymphoid tissue) lymphomas, presumably due to the  eradication of tumorigenic Helicobacter pylori infection. This agent also  acts as a biological response modulator, possibly inhibiting angiogenesis and  tumor growth through alterations in growth factor .

l  包装与存储

包 装

1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov