产品名称

艾乐替尼(Alectinib)

一般描述

Alectinib(艾乐替尼) is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity.

别 称

9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile; CH5424802;Alecensa

纯 度

≥98%(HPLC)

CAS NO.

1256580-46-7

分子式

C³⁰H³⁴N⁴O²

分子量

482.628

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

浅棕黄色固体

溶解性(25℃)

DMSO

~0.5mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Alectinib is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, alectinib binds to and inhibits ALK kinase, ALK fusion proteins as well as the gatekeeper mutation ALKL1196M known as one of the mechanisms of acquired resistance to small-molecule kinase inhibitors. The inhibition leads to disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors.

l  包装与存储

包 装

5mg; 25mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov