产品名称

Veliparib(ABT-888)

一般描述

Veliparib is a potent inhibitor of PARP1 and PARP2. It is inactive to SIRT2.

别 称

2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide; NSC 737664

纯 度

≥98.0%(HPLC)

CAS NO.

912444-00-9

分子式

C¹³H¹⁶N⁴O

分子量

244.296

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25℃)

DMSO

≥15mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Veliparib is a poly(ADP-ribose) polymerase (PARP) -1 and -2 inhibitor with chemosensitizing and antitumor activities. With no antiproliferative effects as a single agent at therapeutic concentrations, ABT-888 inhibits PARPs, thereby inhibiting DNA repair and potentiating the cytotoxicity of DNA-damaging agents. PARP nuclear enzymes are activated by DNA single or double strand breaks, resulting in the  poly(ADP-ribosyl)ation of other nuclear DNA binding proteins involved in DNA  repair; poly(ADP-ribosyl)ation contributes to efficient DNA repair and to survival of proliferating cells exposed to mild genotoxic stresses as induced by as oxidants, alkylating agents or ionizing radiation.

l  包装与存储

包 装

5mg; 25mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov