产品名称

瑞格非尼(Regorafenib)

一般描述

Regorafenib(瑞格非尼) is an oral multi-kinase inhibitor, and Cytochrome P450 2C9 Inhibitor.

别 称

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide; BAY 73-4506;

纯 度

≥98.0%(HPLC)

CAS NO.

755037-03-7

分子式

C²¹H¹⁵ClF⁴N⁴O³

分子量

482.82

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

Very  slightly soluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Regorafenib is an orally bioavailable small molecule with potential antiangiogenic and antineoplastic activities. Regorafenib binds to and inhibits vascular endothelial growth factor receptors (VEGFRs) 2 and 3, and Ret, Kit, PDGFR and Raf kinases, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation. VEGFRs are receptor tyrosine kinases that play important roles in tumor angiogenesis; the receptor tyrosine kinases RET, KIT, and PDGFR, and the serine/threonine-specific Raf kinase are involved in tumor cell signaling.

l  包装与存储

包 装

25mg; 100mg; 500mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov