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详细介绍
l 基本信息 |
产品名称 | 帕唑帕尼(Pazopanib) |
一般描述 | Pazopanib(帕唑帕尼) is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. |
别 称 | 5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide; GW786034 |
纯 度 | ≥98.0%(HPLC) | CAS NO. | 444731-52-6 |
分子式 | C21H23N7O2S | 分子量 | 437.52 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 白色或类白色固体 |
溶解性(25℃) | DMSO | ≥50mg/mL |
乙醇 | Very slightly soluble |
水 | Insoluble |
l 生物学信息 |
生物活性/药理作用 | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated. |
l 包装与存储 |
包 装 | 25mg; 100mg; 500mg |
存储温度 | -20℃ |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
