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详细介绍
l 基本信息 |
产品名称 | Poziotinib |
一般描述 | Poziotinib (HM781-36B) is an irreversible pan-HER inhibitor. |
别 称 | 1-[4-[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]prop-2-en-1-one; HM-78136B |
纯 度 | ≥98.0%(HPLC) | CAS NO. | 1092364-38-9 |
分子式 | C23H21Cl2FN4O3 | 分子量 | 491.34 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 固体 |
溶解性(25℃) | DMSO | ≥50mg/mL |
乙醇 | Very slightly soluble |
水 | Insoluble |
l 生物学信息 |
生物活性/药理作用 | Poziotinib is an orally bioavailable, quinazoline-based, mall-molecular and irreversible pan-epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity. Poziotinib inhibits EGFR (HER1 or ErbB1), HER2, HER4 and EGFR mutants, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. EGFRs, cell surface receptor tyrosine kinases, are often upregulated in a variety of cancer cell types and play key roles in cellular proliferation and survival. |
l 包装与存储 |
包 装 | 5mg; 25mg; 100mg |
存储温度 | -20℃ |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
