产品名称

四环素碱(Tetracycline)

一般描述

Tetracycline(四环素碱) is an oral, broad-spectrum antibiotic used to treat mild-to-moderate infections due to susceptible microbial organisms.

别 称

(4S,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide; Achromycin

纯 度

≥90.0%(HPLC)

CAS NO.

60-54-8

分子式

C²²H²⁴N²O⁸

分子量

444.44

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

浅棕色或棕色固体

溶解性(25℃)

DMSO

≥25mg/mL

乙醇

≥20mg/mL

水

Very slightly soluble

l  生物学信息

生物活性/药理作用

Tetracycline is a broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline binds to the 30S ribosomal subunit, interferes with the binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis.

Tetracycline passively diffuses through porin channels in the bacterial membrane and   reversibly binds to the 30S ribosomal subunit, preventing binding of tRNA to the mRNA-ribosome complex, and thus interfering with protein synthesis.

l  包装与存储

包 装

250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov