产品名称

硫酸萘替米星(Netilmicin sulfate)

一般描述

Netilmicin Sulfate is an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity.

别 称

(2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4-amino-3-[[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-6-(ethylamino)-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol; sulfuric acid;Certomycin; 1-N-Ethylsisomicin

纯 度

≥98.0%(HPLC)

CAS NO.

56391-57-2

分子式

C⁴²H⁹²N¹⁰O³⁴S⁵

分子量

1441.55

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

浅黄色或黄色固体

溶解性(25℃)

DMSO

Very slightly soluble

乙醇

Insoluble

水

≥50mg/mL

l  生物学信息

生物活性/药理作用

Netilmicin Sulfate is the sulfate salt form of netilimicin, a semisynthetic, water soluble aminoglycoside antibiotic. Netilmicin is derived from sisomicin, a naturally occurring aminoglycoside antibiotic produced by the fermentation of Micromonospora inyoensis.   Netilmicin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, netilmicin induces misreading of the mRNA template and causes translational shift, thereby results in premature termination. This eventually leads to bacterial cell death.

l  包装与存储

包 装

25mg; 100mg; 250mg; 1g

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov