产品名称

Sasapyrine(双水杨酸酯)

一般描述

Sasapyrine (salsalate) is a nonsteroidal oral anti-inflammatory agent.

别 称

NSC-49171; 2-(2-hydroxybenzoyl)oxybenzoic acid

纯 度

≥98.0%(HPLC)

CAS NO.

552-94-3

分子式

C¹⁴H¹⁰O⁵

分子量

258.229

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25°C)

DMSO

≥45mg/ml

乙醇

≥45mg/ml

水

Insoluble

l  生物学信息

生物活性/药理作用

Salsalate is an orally available salicylate and non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic and antipyretic activities. As a prodrug, salsalate is hydrolyzed to salicylic acid which inhibits the  of cyclooxygenase (COX) enzymes. This prevents the conversion of arachidonic acid into prostaglandin precursors and leads to decreased formation of prostaglandins that are involved in pain, fever and inflammation. In addition, salsalate appears to inhibit nuclear factor-kappa B (NF-kB), thereby preventing activation of the NF-kB-mediated pathway and the  of genes involved in inflammation.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov