产品名称

Nicorandil(尼可地尔)

一般描述

Nicorandil is a potassium channel activator, and stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP).

别 称

SG-75; 2-(pyridine-3-carbonylamino)ethyl nitrate

纯 度

≥98.0%(HPLC)

CAS NO.

65141-46-0

分子式

C⁸H⁹N³O⁴

分子量

211.177

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色结晶

溶解性(25°C)

DMSO

≥25mg/ml

乙醇

≥25mg/ml

水

≥5mg/ml

l  生物学信息

生物活性/药理作用

Nicorandil is a niacinamide derivative, a plasma membrane adenosine triphosphate (ATP)-sensitive potassium  (K₊) (KATP) channel activator and a nitric oxide (NO) donor, with vasodilatory, antihypertensive and potential cardio- and lung-protective activities. Upon administration, nicorandil binds to and opens KATP channels, which causes relaxation of vascular smooth muscles, stimulates vasodilatation, reduces vasoresistance, decreases blood pressure and protects the myocardium against ischemia. In addition, nicorandil exerts nitrate-like properties, through the stimulation of guanylate cyclase, the downregulation of Rho-kinase activity and the further promotion of venous vasodilation. Although the mechanism of action has not been fully elucidated, nicorandil may exhibit protective activity against radiation-induced lung and heart toxicity, possibly by preventing both accumulation of reactive oxygen species (ROS) and ROS-induced cellular damage.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov