产品名称

Diazoxide(氯甲苯噻嗪)

一般描述

Diazoxide is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions.

别 称

Proglycem; 二氮嗪

纯 度

≥98%(HPLC)

CAS NO.

364-98-7

分子式

C⁸H⁷ClN²O²S

分子量

230.67

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

灰色固体

溶解性(25°C)

DMSO

≥35mg/ml

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Diazoxide is a benzothiadiazine derivate with antihypertensive and hyperglycemic activities. Diazoxide increases membrane permeability to potassium ions in vascular smooth muscle, thereby stabilizing the membrane action potential and preventing vascular smooth muscle contraction; this results in peripheral vasodilatation and decreases in peripheral vascular resistance. This agent also inhibits insulin release by interacting with ATP-sensitive potassium channels of pancreatic islet beta-cells.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov