产品名称

Amiloride HCl(盐酸阿米洛利)

一般描述

Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).

别 称

3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide; hydrochloride

纯 度

≥98.0%(HPLC)

CAS NO.

2016-88-8

分子式

C⁶H⁹Cl²N⁷O

分子量

266.086

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

浅黄色固体

溶解性(25°C)

DMSO

≥45mg/ml

乙醇

~5mg/ml

水

~5mg/ml

l  生物学信息

生物活性/药理作用

Amiloride Hydrochloride is the hydrochloride salt of amiloride, a synthetic pyrazine derivative with antikaliuretic and diuretic properties. Amiloride inhibits sodium channels located in the distal tubules and collecting ducts of the kidney, thereby preventing the absorption of sodium and increasing its excretion along with water, to produce naturesis. In response to the hypernatremic conditions in the kidney, the plasma membrane becomes hyperpolarized and electrochemical forces are reduced, which then prevents the excretion of potassium and hydrogen into the lumen.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov