产品名称

3-硝基-4-碘苯甲酰胺(Iniparib (BSI-201))

一般描述

Iniparib is a small molecule iodobenzamide with potential cytotoxic and antineoplastic activities.

别 称

4-iodo-3-nitrobenzamide; NSC-746045, IND-71677, BSI-201

纯 度

≥98.0%(HPLC)

CAS NO.

160003-66-7

分子式

C⁷H⁵IN²O³

分子量

292.03

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥25mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Iniparib is a small molecule iodobenzamide with potential cytotoxic and antineoplastic activities. Although the mechanism of action is unknown, iniparib appears to be cytotoxic in cells with DNA alterations or DNA damage, like that found in tumor cells with mutations in the ataxia telangiectasia mutated (ATM) gene. ATM encodes a serine/threonine protein kinase and mutations of the gene are associated with ataxia telangiectasia and contribute to certain cancers such as T-cell acute lymphoblastic leukemia, B-cell chronic lymphocytic leukemia and B-cell non-Hodgkin lymphomas.

Iniparib is a PARP1 inhibitor with demonstrated effectiveness in triple-negative breast cancer (TNBC).

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov