产品名称

盐酸二甲双胍(Metformin HCl)

一般描述

Metformin Hydrochloride(盐酸二甲双胍) is the hydrochloride salt of the biguanide metformin with antihyperglycemic and potential antineoplastic activities.

别 称

3-(diaminomethylidene)-1,1-dimethylguanidine;hydrochloride

纯 度

≥98.0%(HPLC)

CAS NO.

1115-70-4

分子式

C⁴H¹¹N⁵·HCl

分子量

165.62

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25℃)

DMSO

Insoluble

乙醇

Insoluble

水

≥30mg/mL(warmed)

l  生物学信息

生物活性/药理作用

Metformin Hydrochloride is the hydrochloride salt of the biguanide metformin with antihyperglycemic and potential antineoplastic activities. Metformin inhibits complex I (NADPH:ubiquinone oxidoreductase) of the mitochondrial respiratory chain, thereby increasing the cellular AMP to ATP ratio and leading to activation of  AMP-activated protein kinase (AMPK) and regulating AMPK-mediated  tranion of target genes. This eventually prevents hepatic gluconeogenesis, enhances insulin sensitivity and fatty acid oxidation and  ultimately leads to a decrease in glucose levels. Metformin may exert  antineoplastic effects through AMPK-mediated or AMPK-independent inhibition of mammalian target of rapamycin (mTOR), which is up-regulated in many cancer  tissues. Furthermore, this agent also inhibits tumor cell migration and  invasion by inhibiting matrix metalloproteinase-9 (MMP-9) which is mediated through the suppression of tranion activator protein-1 (AP-1)  activation.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov