产品名称

Isotretinoin(异维A酸)

一般描述

It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.

别 称

13-cis retinoic acid; (2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid

纯 度

≥98.0%(HPLC)

CAS NO.

4759-48-2

分子式

C²⁰H²⁸O²

分子量

300.442

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

黄色或橙黄色固体

溶解性(25°C)

DMSO

≥45mg/ml

乙醇

Very slightly soluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Isotretinoin is a naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as tranion factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov