产品名称

Flucytosine(5-氟胞嘧啶)

一般描述

Flucytosine (5-Fluorocytosine, 5-FC) is an antifungal drug with IC50 of 0.93 μM in C. albicans.

别 称

6-amino-5-fluoro-1H-pyrimidin-2-one

纯 度

≥98.0%(HPLC)

CAS NO.

2022-85-7

分子式

C⁴H⁴FN³O

分子量

129.094

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25°C)

DMSO

Slightly soluble

乙醇

Insoluble

水

Slightly soluble

l  生物学信息

生物活性/药理作用

Flucytosine is a pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity.  After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov