产品名称

Dexmedetomidine(右美托咪定)

一般描述

Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.

别 称

5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole

纯 度

≥98.0%(HPLC)

CAS NO.

113775-47-6

分子式

C¹³H1⁶N²

分子量

200.285

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25°C)

DMSO

≥35mg/mL

乙醇

≥35mg/mL

水

≥35mg/mL

l  生物学信息

生物活性/药理作用

Dexmedetomidine is an imidazole derivate and active d-isomer of medetomidine with analgesic, anxiolytic and sedative properties. Dexmedetomidine selectively binds to presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibit sympathetic activity, thereby leading to sedation and anxiolysis. The analgesic effect of this agent is mediated by binding to alpha-2 adrenoceptors in the spinal cord.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov