Regorafenib Monohydrate
商品编号:
TS2370
备注:
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详细介绍
l 基本信息 |
产品名称 | Regorafenib Monohydrate(瑞格非尼一水合物) |
一般描述 | Regorafenib is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, KIT, RET, RAF-1, B-RAF and B-RAF(V600E) respectively. |
别 称 | Regorafenib Monohydrate; Regorafenib Hydrate |
纯 度 | ≥99.0%(HPLC) | CAS NO. | 1019206-88-2 |
分子式 | C21H17ClF4N4O4 | 分子量 | 500.83 |
适用范围 | 生物试剂,适用于细胞培养等 |
l 理化信息 |
外 观 | 固体 |
溶解性(25°C) | DMSO | ≥50mg/ml |
l 生物学信息 |
生物活性/药理作用 | Regorafenib hydrate is a hydrate that is the monohydrate form of anhydrous regorafenib. Used for for the treatment of metastatic colorectal cancer in patients who have previously received chemotherapy, anti-EGFR or anti-VEGF therapy. It has a role as an antineoplastic agent, a tyrosine kinase inhibitor and a hepatotoxic agent. It contains a regorafenib. |
l 存储 |
存储温度 | -20°C |
l 注意事项及免责声明 |
本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |