产品名称

Arformoterol Tartrate(酒石酸福莫特罗)

一般描述

Formoterol tartrate is a salt form of Formoterol. Formoterol is a beta 2 adrenergic receptor agonist that can be used in the treatment of asthma and COPD. It has an extended duration of action (up to 12 hours) compared to short-acting β2 agonists such as salbutamol (4–6 hours). Formoterol can be used as "symptom controllers" to supplement prophylactic corticosteroid therapy.

别 称

(R,R)-Formoterol Tartrate

纯 度

≥98.0%(HPLC)

CAS NO.

200815-49-2

分子式

C²³H³⁰N²O¹⁰

分子量

494.4917

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至米色固体

溶解性(25°C)

DMSO

≥50mg/ml

l  生物学信息

生物活性/药理作用

Arformoterol Tartrate is the tartrate salt of arformoterol, the (R,R)-enantiomer of formoterol and a long-acting beta-2 adrenergic agonist with bronchodilator activity. Arformoterol selectively binds to and activates beta-2 adrenergic receptors in bronchiolar smooth muscle, thereby causing stimulation of adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased intracellular cAMP levels cause relaxation of bronchial smooth muscle and lead to an inhibition of release of inflammatory mediators from mast cells. This may eventually lead to an improvement of airway function.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov