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详细介绍
l 基本信息 |
产品名称 | Tasisulam |
一般描述 | Tasisulam is an antitumor agent and an apoptosis inducer via the intrinsic pathway. |
别 称 | LY573636; N-(5-bromothiophen-2-yl)sulfonyl-2,4-dichlorobenzamide |
纯 度 | ≥98.5%(HPLC) | CAS NO. | 519055-62-0 |
分子式 | C11H6BrCl2NO3S2 | 分子量 | 415.11 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 固体 |
溶解性(25°C) | DMSO | ≥50mg/ml |
乙醇 | ≥50mg/ml |
水 | Very slightly soluble |
l 生物学信息 |
生物活性/药理作用 | Tasisulam is an acyl-sulfonamide with potential antineoplastic activity. Selectively toxic towards tumor cells, tasisulam appears to induce tumor cell apoptosis by a mitochondrial-targeted mechanism involving the loss of mitochondrial membrane potential and induction of reactive oxygen species (ROS). In combination with an angiogenesis inhibitor, this agent may exhibit synergistic antiangiogenic activity. |
l 存储 |
存储温度 | -20°C |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
