Sotagliflozin (LX4211)
商品编号：
TS3374
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详细介绍
l 基本信息 |
产品名称 | Sotagliflozin |
一般描述 | Sotagliflozin is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively. |
别 称 | LX4211 |
纯 度 | ≥98.5%(HPLC) | CAS NO. | 1018899-04-1 |
分子式 | C21H25ClO5S | 分子量 | 424.94 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 固体 |
溶解性(25°C) | DMSO | ≥50mg/ml |
乙醇 | ≥5mg/ml |
水 | Very slightly soluble |
l 生物学信息 |
生物活性/药理作用 | Sotagliflozin is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity. Upon oral administration,
sotagliflozin binds to and blocks both SGLT1 in the gastrointestinal (GI) tract and SGLT2 in the kidneys, thereby suppressing the absorption of glucose from the GI tract and the reabsorption of glucose by the proximal tubule into the bloodstream, respectively. This decreases glucose uptake and enhances the urinary excretion of glucose, which lowers and/or normalizes blood glucose levels. SGLT1 is the primary transporter responsible for glucose absorption from the GI tract. SGLT2, a transport protein exclusively expressed in the proximal renal tubules, mediates approximately 90% of renal glucose reabsorption from tubular fluid. |
l 存储 |
存储温度 | -20°C |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
