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  • DNA Ligase from T4-infected Escherichia coli
    TS0642

    CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively. It is less potent to FGFR3, GSK3β, PDGFRβ, etc.

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  • DNA Ligase from T4-infected Escherichia coli
    TS0643

    AT7519 is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM. It is less potent to CDK3 and little active to CDK7.

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  • DNA Ligase from T4-infected Escherichia coli
    TS0657

    BS-181 HCl is a highly selective CDK7 inhibitor with IC50 of 21 nM. It is more than 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9.

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  • DNA Ligase from T4-infected Escherichia coli
    TS0703

    Azathioprine(硫唑嘌呤) is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases.

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  • DNA Ligase from T4-infected Escherichia coli
    TS0810

    BMS-265246 is a potent and selective CDK1/2 inhibitor with IC50 of 6 nM/9 nM in a cell-free assay. It is 25-fold more selective for CDK1/2 than CDK4.

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  • DNA Ligase from T4-infected Escherichia coli
    TS0903

    Tosyl-L-Arginine Methyl Ester (TAME) is an APC inhibitor.

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  • DNA Ligase from T4-infected Escherichia coli
    TS1110

    CHIR-124 is a novel and potent Chk1 inhibitor with IC50 of 0.3 nM in a cell-free assay. It shows 2,000-fold selectivity against Chk2, 500- to 5,000-fold less activity against CDK2/4 and Cdc2.

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  • DNA Ligase from T4-infected Escherichia coli
    TS1113

    R547 is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases.

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