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  • DNA Ligase from T4-infected Escherichia coli
    TS3385

    RHPS4 is a potent inhibitor of Telomerase at submicromolar.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3398

    Halofuginone is the competitively inhibitor of  prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3447

    Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3456

    SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3485

    SMI is considered a general-purpose activator for DNA and RNA synthesis.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3487

    CeMMEC1 is an N-methylisoquinolinone derivative that inhibits the second bromodomain of TAF1 (IC50=0.9 μM).

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  • DNA Ligase from T4-infected Escherichia coli
    TS3488

    CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 μM).

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  • DNA Ligase from T4-infected Escherichia coli
    TS3502

    NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles, showing 150-fold selectivity for PARP-1 over PARP-2 (Kd 0.009 μM vs 1.39 μM, respectively).

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