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  • DNA Ligase from T4-infected Escherichia coli
    TS1112

    NVP-BSK805 2HCl is a potent and selective ATP-competitive JAK2 inhibitor with IC50 of 0.5 nM,>20-fold selectivity towards JAK1, JAK3 and TYK2.

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  • DNA Ligase from T4-infected Escherichia coli
    TS1164

    CEP33779 is a selective JAK2 inhibitor with IC50 of 1.8 nM, >40- and >800-fold versus JAK1 and TYK2.

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  • DNA Ligase from T4-infected Escherichia coli
    TS1194

    WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM, no activity against JAK1 or JAK2, also inhibits EGFR, Src, Abl, VEGFR and MAPK, prevents Stat3, but not Stat5 phosphorylation.

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  • DNA Ligase from T4-infected Escherichia coli
    TS1209

    S-Ruxolitinib is the chirality of INCB018424, which is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3.

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  • DNA Ligase from T4-infected Escherichia coli
    TS2484

    Ruxolitinib Phosphate(鲁索利替尼磷酸盐) is the phosphate salt form of ruxolitinib, an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities.

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  • DNA Ligase from T4-infected Escherichia coli
    TS2885

    XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, exhibiting >50-fold selectivity over JAK1, JAK3 and TYK2.

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  • DNA Ligase from T4-infected Escherichia coli
    TS2889

    CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3, respectively.  

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  • DNA Ligase from T4-infected Escherichia coli
    TS2928

    BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively.

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