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  • DNA Ligase from T4-infected Escherichia coli
    TS2886

    Wnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM in HEK293 cells.

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  • DNA Ligase from T4-infected Escherichia coli
    TS2899

    IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM in a cell-free assay, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses.

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  • DNA Ligase from T4-infected Escherichia coli
    TS2903

    SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM.

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  • DNA Ligase from T4-infected Escherichia coli
    TS2937

    Glasdegib (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM.  

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  • DNA Ligase from T4-infected Escherichia coli
    TS2941

    Crenigacestat is an oral Notch inhibitor with an IC50 of 0.41nM.

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  • DNA Ligase from T4-infected Escherichia coli
    TS2993

    IWP-L6 is a highly potent Porcn inhibitor with EC50 of 0.5 nM.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3045

    FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3080

    FH535 is a Wnt/β-catenin signaling inhibitor and also a dual PPARγ and PPARδ antagonist.  

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